Sarcotrine G, a New Derivative Isolated from a Marine Sponge Sarcotragus Species
Sarcotrine G, a New Derivative Isolated from a Marine Sponge Sarcotragus Species
노정래(군산대학교); 황병수(군산대학교); Su Young Park(군산대학교); 박명길(광주대학교)
12권 1호, 33~39쪽
초록
Four sesterterpenoids were isolated from AMPK activity-guided fraction of marine sponge Sarcotragus species. Their planar structures were determined from combination of extensive 1D and 2D NMR experiments and MS data, and the configuration at the chiral centers were assigned by comparison with the 1H and 13C chemical shifts of the known compounds. Among four compounds, compound 2 was found to be a new sarcotrine derivative. Though not strong, compounds 1-4 moderately showed AMPK activation effect on L6 myoblast cell through Western Blot analysis.
Abstract
Four sesterterpenoids were isolated from AMPK activity-guided fraction of marine sponge Sarcotragus species. Their planar structures were determined from combination of extensive 1D and 2D NMR experiments and MS data, and the configuration at the chiral centers were assigned by comparison with the 1H and 13C chemical shifts of the known compounds. Among four compounds, compound 2 was found to be a new sarcotrine derivative. Though not strong, compounds 1-4 moderately showed AMPK activation effect on L6 myoblast cell through Western Blot analysis.
- 발행기관:
- 한국자기공명학회
- 분류:
- 화학