산겨릅나무 추출물의 간암세포의 증식억제 효과
Effect of Acer tegmentosum M. Extracts on Hepatocarcinoma Cell
권하나(영남대학교); 방우석(영남대학교); 김주영(영남대학교); 박정륭(영남대학교); 전정례(영남대학교)
43권 6호, 787~790쪽
초록
The objective of this study was to investigate the anticancer effects of Acer tegmentosum M. extracts. HepG2hepatocarcinoma cells were treated with ethanol, chloroform, ethylacetate, butanol, aqueous fraction and hot water extract. The antiproliferative effect was evaluated by trypan blue exclusion, MTT-based viability assay and morphology. The trypan blue test showed that anticancer effect of the A. tegmentosum M. extracts on HepG2 cells increased gradually in proportion to the increasing concentration of the fractions. The butanol fraction showed the highest anticancer activity against HepG2cells (p<0.05). The MTT assay indicated that the growth inhibition by the butanol fraction was dose-dependent. These results suggest that A. tegmentosum M. has the potential to inhibit the growth of hepatocarcinoma cells.
Abstract
The objective of this study was to investigate the anticancer effects of Acer tegmentosum M. extracts. HepG2hepatocarcinoma cells were treated with ethanol, chloroform, ethylacetate, butanol, aqueous fraction and hot water extract. The antiproliferative effect was evaluated by trypan blue exclusion, MTT-based viability assay and morphology. The trypan blue test showed that anticancer effect of the A. tegmentosum M. extracts on HepG2 cells increased gradually in proportion to the increasing concentration of the fractions. The butanol fraction showed the highest anticancer activity against HepG2cells (p<0.05). The MTT assay indicated that the growth inhibition by the butanol fraction was dose-dependent. These results suggest that A. tegmentosum M. has the potential to inhibit the growth of hepatocarcinoma cells.
- 발행기관:
- 한국식품과학회
- 분류:
- 식품과학