Synergistic Effect of the Novel Benzochalcone Derivative DK-78 and Doxorubicin on MCF7-VN Breast Cancer Stem Cells
Synergistic Effect of the Novel Benzochalcone Derivative DK-78 and Doxorubicin on MCF7-VN Breast Cancer Stem Cells
조문제(제주대학교); 박상규(대구대학교); 김소미(제주대학교); 고동수(동덕여자대학교)
56권 5호, 631~635쪽
초록
Several naturally occurring or synthesized forms of chalcone have been shown to possess multiple biological properties,including antitumor activities. A novel synthetic flavonoid, the benzochalcone derivative DK-78, was administered with the anticancer drug doxorubicin to two breast cancer cell lines (MCF7-VN and MDA-MB-231), and was evaluated for a synergistic cytotoxic effect. DK-78 reduced the expression of mesenchymal marker proteins and reduced cell migration and attachment. Sequential treatment with DK-78 and doxorubicin showed synergistic effects.
Abstract
Several naturally occurring or synthesized forms of chalcone have been shown to possess multiple biological properties,including antitumor activities. A novel synthetic flavonoid, the benzochalcone derivative DK-78, was administered with the anticancer drug doxorubicin to two breast cancer cell lines (MCF7-VN and MDA-MB-231), and was evaluated for a synergistic cytotoxic effect. DK-78 reduced the expression of mesenchymal marker proteins and reduced cell migration and attachment. Sequential treatment with DK-78 and doxorubicin showed synergistic effects.
- 발행기관:
- 한국응용생명화학회
- 분류:
- 농화학