Functional poly(L-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties
Functional poly(L-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties
이민지(가톨릭대학교); 이은성(가톨릭대학교); 오남묵(한국생명과학); 오경택(중앙대학교); 윤유석(성균관대학교)
44권 5호, 351~356쪽
초록
We developed novel poly(L-lysine) [poly(Lys)]derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemicalreaction of poly(Lys) and 3-diethylaminopropyl isothiocyanate(DEAP), and was coupled with poly(ethyleneglycol) (PEG). The obtained poly(Lys-DEAP)-b-PEG wascrosslinked by genipin (crosslinking agent) in an oil/wateremulsion condition, producing poly(Lys) derivative nanogels. These nanogels (*95 nm in diameter, pH 7.4)showed volume expansion (*200 nm in diameter) in theendosomal pH (*pH 6.0) due to extensive protonabsorption of DEAP moieties in the crosslinked nanogelcore. These nanogels reversibly swelled at pH 6.0 andshrank at pH 7.4, correspond to maximized drug release atpH 6.0 and minimized drug release at pH 7.4. We concludethat this nanogel system will have great potential for tumortherapy.
Abstract
We developed novel poly(L-lysine) [poly(Lys)]derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemicalreaction of poly(Lys) and 3-diethylaminopropyl isothiocyanate(DEAP), and was coupled with poly(ethyleneglycol) (PEG). The obtained poly(Lys-DEAP)-b-PEG wascrosslinked by genipin (crosslinking agent) in an oil/wateremulsion condition, producing poly(Lys) derivative nanogels. These nanogels (*95 nm in diameter, pH 7.4)showed volume expansion (*200 nm in diameter) in theendosomal pH (*pH 6.0) due to extensive protonabsorption of DEAP moieties in the crosslinked nanogelcore. These nanogels reversibly swelled at pH 6.0 andshrank at pH 7.4, correspond to maximized drug release atpH 6.0 and minimized drug release at pH 7.4. We concludethat this nanogel system will have great potential for tumortherapy.
- 발행기관:
- 한국약제학회
- 분류:
- 약학