탈세포 장기 지지체의 제조 및 분석기법

Organ transplantation has often been successful for treatment of end-stage organ failure. However, theshortage of donor organ still remains problematic in clinical practices. As an alternative, the tissue-engineeringapproach for functional organ replacement has been extensively studied. More recently, decellularized organs havebeen emerged as a promising scaffold for reconstruction of the complicated organs (e.g., heart, liver, lung and kidney). The ideal decellularized organ scaffolds need to contain extracellular matrix (ECM), bioactive molecules, vascularsystems and tissue microarchitecture. To fulfill these requirements, physical, chemical, and biologicaltechniques have been adapted in the process of organ decellularization. In this review, the representative techniquesfor the organ decellularization and their characterization as well as considerations for implantation are discussed.