Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Roshan R. Kulkarni(충남대학교); 조아름(충남대학교); 김영호(충남대학교); 나민균(충남대학교)
21권 4호, 293~296쪽
초록
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 ± 1.0 μM.
Abstract
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 ± 1.0 μM.
- 발행기관:
- 한국생약학회
- 분류:
- 약학