Synthesis and Cell Death Mechanism of a Militarin Derivative
Synthesis and Cell Death Mechanism of a Militarin Derivative
Fei Chen(Kangwon National University); Deok Hyo Yoon(Kangwon National University); Dinneswara Reddy(Kangwon National University); Changwoo Han(Kangwon National University); 최성아(충남대학교); 조재열(성균관대학교); 성기호(가톨릭관동대학교); 황기철(가톨릭관동대학교); 김태웅(강원대학교); 박해일(강원대학교)
37권 3호, 287~293쪽
초록
Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.
Abstract
Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.
- 발행기관:
- 대한화학회
- 분류:
- 화학