Hypolipidemic and hypoglycemic activities of a oleanolic acid derivative from Malva parviflora on streptozotocin-induced diabetic mice

One new oleanolic acid derivative, 2a,3b,23a,29atetrahydroxyolean-12(13)-en-28-oic acid (1) was isolatedfrom the aerial parts of Malva parviflora. Their structure wascharacterized by spectroscopic methods. The hypolipidemicand hypoglycemic activities of 1 was analyzed in in streptozotocin(STZ)-nicotinamide-induced type 2 diabetes inmice (MD) and type 1 diabetes in streptozotocin-induceddiabetic mice (SD). Triterpene was administered orally atdoses of 20 mg/kg for 4 weeks. Organ weight, body weight,glucose, fasting insulin, cholesterol-related lipid profileparameters, glutamate oxaloacetate transaminase (SGOT),glutamate pyruvate transaminase (SGPT), serum alkalinephosphatase (SALP), glucokinase, hexokinase, glucose-6-phosphatase activities and glycogen in liver were measuredafter 4 weeks of treatment. The results indicated that 1 regulateglucose metabolism, lipid profile, lipid peroxidation,increased body weight, glucokinase and hexokinase activitiesinhibited triglycerides, total cholesterol, low densitylipoproteins level, SGOT, SGPT, SALP, glycogen in liverand glucose-6-phosphatase. In addition, improvement ofinsulin resistance and protective effect for pancreatic b-cells,also 1 may changes the expression of pro-inflammatorycytokine (IL-6 and TNF-a levels) and enzymes (PAL2,COX-2, and LOX). The results suggest that 1 has hypolipidemicand hypoglycemic, anti-inflammatory, activities,improve insulin resistance and hepatic enzymes in streptozotocin-induced diabetic mice.