Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
한가득(중앙대학교); 김재원(중앙대학교); 노승현(중앙대학교); 김신웅(중앙대학교); 장의찬(중앙대학교); 나재운(순천대학교); 이영기(Samsung SDI Company Ltd.); 김미경(중앙대학교); Yoshihiro Ito(Nano Medical Engineering Laboratory); 손태일(중앙대학교)
70권, 204~210쪽
초록
Post-operative adhesion is a very serious complication in the clinicalfield, frequently occurring aftersurgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfurylhyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and antiinflammatoryapplications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affordingfurfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examinedin chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is asuitable anti-adhesion and anti-inflammation agent.
Abstract
Post-operative adhesion is a very serious complication in the clinicalfield, frequently occurring aftersurgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfurylhyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and antiinflammatoryapplications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affordingfurfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examinedin chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is asuitable anti-adhesion and anti-inflammation agent.
- 발행기관:
- 한국공업화학회
- 분류:
- 화학공학