Repellent efficacy and safety evaluation of IR3535 derivative against Aedes albopictus, Culex pipiens pallens and Aedes togoi
Repellent efficacy and safety evaluation of IR3535 derivative against Aedes albopictus, Culex pipiens pallens and Aedes togoi
박성진(계명대학교); 유미희(계명대학교); 김지은(계명대학교); 박민주(계명대학교); 이인선(계명대학교); 이지훈(계명대학교); 이진호(계명대학교); 김배환(계명대학교); 이동규(고신대학교); 이삼빈(계명대학교)
42권 6호, 299~307쪽
초록
The IR3535 derivative (LJH158), in which the ethyl ester of IR3535 was converted to methyl ester, was synthesized and studied as a new mosquito repellent. The repellent efficacy of LJH158 was compared with that of DEET against Aedes albopictus, Culex pipiens pallens and Aedes togoi. Also, the aromatic repellent tests were conducted with mixtures of repellents and the essential oils of cinnamon, which were obtained by supercritical fluid extraction. In addition, the safety issues of LJH158 were monitored using single oral dose safety methods and eye irritation, and skin irritation tests. The results of repellent efficacy in both biting and aromatic tests and safety tests demonstrate that LJH158 has high potential to be used as a new repellent or in combination with other repellents.
Abstract
The IR3535 derivative (LJH158), in which the ethyl ester of IR3535 was converted to methyl ester, was synthesized and studied as a new mosquito repellent. The repellent efficacy of LJH158 was compared with that of DEET against Aedes albopictus, Culex pipiens pallens and Aedes togoi. Also, the aromatic repellent tests were conducted with mixtures of repellents and the essential oils of cinnamon, which were obtained by supercritical fluid extraction. In addition, the safety issues of LJH158 were monitored using single oral dose safety methods and eye irritation, and skin irritation tests. The results of repellent efficacy in both biting and aromatic tests and safety tests demonstrate that LJH158 has high potential to be used as a new repellent or in combination with other repellents.
- 발행기관:
- 한국곤충학회
- 분류:
- 생물학