Ultra-trace level voltammetric sensor for MB in human plasma based on a carboxylic derivative of Calix[4]resorcinarene capped silver nanoparticles
Ultra-trace level voltammetric sensor for MB in human plasma based on a carboxylic derivative of Calix[4]resorcinarene capped silver nanoparticles
Abdul Rehman Umar(University of Karachi); Kashif Hussain(University of Karachi); Zara Aslam(University of Karachi); Muhammad Anwar Ul Haq(University of Karachi); Haji Muhammadb(Federal Urdu University of Arts, Sciences and Technology); Sirajuddin(University of Karachi); Muhammad Raza Shah(University of Karachi)
107권, 81~92쪽
초록
This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a threestep protocol confirmed by proton nuclear magnetic resonance (1H NMR) spectroscopy and Electrosprayionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and cappingmaterial for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium underthe combined influence of dilute alkali and heat at 90 C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV–Visible (UV–Vis) spectroscopy,Fourier transform infra-red (FTIR) spectroscopy, atomic force microscopy (AFM), dynamic light scattering(DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highlysensitive and extremely selective voltammetric sensor for low level detection of methylene blue drugin the linear working range of 1–30 nM with limit of detection (LOD) and limit of quantification (LOQ)as 0.16 nM and 0.53 nM respectively. The developed sensor was successfully used for sensing of MB inhuman blood plasma.
Abstract
This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a threestep protocol confirmed by proton nuclear magnetic resonance (1H NMR) spectroscopy and Electrosprayionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and cappingmaterial for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium underthe combined influence of dilute alkali and heat at 90 C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV–Visible (UV–Vis) spectroscopy,Fourier transform infra-red (FTIR) spectroscopy, atomic force microscopy (AFM), dynamic light scattering(DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highlysensitive and extremely selective voltammetric sensor for low level detection of methylene blue drugin the linear working range of 1–30 nM with limit of detection (LOD) and limit of quantification (LOQ)as 0.16 nM and 0.53 nM respectively. The developed sensor was successfully used for sensing of MB inhuman blood plasma.
- 발행기관:
- 한국공업화학회
- 분류:
- 화학공학