Correlation analysis between artemisinin and its derivative contents and trichome characteristics from different Artemisia species
Correlation analysis between artemisinin and its derivative contents and trichome characteristics from different Artemisia species
Park Yun Ji(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Truong To Quyen(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Choi Yeong Bin(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Huynh Phuong Kim(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Moon Jinyoung(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Koo Song Yi(KIST Gangneung Institute of Natural Products); Kim Hyoung Seok(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products); Kim Sang Min(Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products)
67권, 1~13쪽
초록
Artemisia species have significant commercial, medical, and economic value and are widely used in the traditional medicine and pharmaceutical industries. Artemisinin, a powerful antimalarial agent, is an important pharmaceutical metabolite that primarily accumulates within the glandular trichomes (GTs) on the leaf surface of Artemisia plants. Trichomes arising from the elongation of epidermal cells can be classified into GTs and non-glandular trichomes (NGTs) based on their morphology. GTs and NGTs are present in Artemisia species, and the relationship between GTs and artemisinin has been extensively studied; however, the correlation between NGTs and artemisinin remains relatively unexplored. In this study, we inferred artemisinin derivatives and trichome characteristics based on the type of species, developmental stage, and leaf age and conducted correlation analyses to investigate the factors influencing artemisinin content across different Artemisia species. Artemisinin and its derivatives exhibited variations in distribution based on species and leaf age, with a decreasing trend observed across most species as the developmental stage progressed. Noticeable differences among Artemisia species were observed in leaf shape, morphology, and trichome distribution. Although the observed data did not evidently differentiate between species, developmental stage, and leaf age groups, principal component analysis revealed that artemisinin was positively associated with the NGTs density, indicating a correlation coefficient of 0.56 (p < 0.0001). Therefore, the number of NGTs may affect the artemisinin content in different Artemisia species.
Abstract
Artemisia species have significant commercial, medical, and economic value and are widely used in the traditional medicine and pharmaceutical industries. Artemisinin, a powerful antimalarial agent, is an important pharmaceutical metabolite that primarily accumulates within the glandular trichomes (GTs) on the leaf surface of Artemisia plants. Trichomes arising from the elongation of epidermal cells can be classified into GTs and non-glandular trichomes (NGTs) based on their morphology. GTs and NGTs are present in Artemisia species, and the relationship between GTs and artemisinin has been extensively studied; however, the correlation between NGTs and artemisinin remains relatively unexplored. In this study, we inferred artemisinin derivatives and trichome characteristics based on the type of species, developmental stage, and leaf age and conducted correlation analyses to investigate the factors influencing artemisinin content across different Artemisia species. Artemisinin and its derivatives exhibited variations in distribution based on species and leaf age, with a decreasing trend observed across most species as the developmental stage progressed. Noticeable differences among Artemisia species were observed in leaf shape, morphology, and trichome distribution. Although the observed data did not evidently differentiate between species, developmental stage, and leaf age groups, principal component analysis revealed that artemisinin was positively associated with the NGTs density, indicating a correlation coefficient of 0.56 (p < 0.0001). Therefore, the number of NGTs may affect the artemisinin content in different Artemisia species.
- 발행기관:
- 한국응용생명화학회
- 분류:
- 농화학