The Association between Serum Osmolality and Hypertension, Diabetes Mellitus and Kidney Disease

This study aimed to investigate the association between dehydration and hypertension, diabetes mellitus, and kidney disease from subjects who restricted their food and fluid intake before the drawing of blood for a physical test during a national health screening program. In this study, there were 491 samples with valid data regarding the levels of sodium, potassium, blood urea nitrogen, and fasting blood sugar selected to calculate serum osmolality, as an indicator of dehydration. The data were collected from the national health screening examinees from 2017.11.01. to 2017.12.18 at the S Hospital Comprehensive Health Check-up Center. The study group was divided into the normal group (<295 mOsm) and the dehydrated group (≥295 mOsm). Multiple regression analysis showed no significant impact of dehydration on diastolic blood pressure for this study group, but the model with glycated hemoglobin and glomerular filtration rate showed a high enough correlation to confirm dehydration as a significant predictor of diseases. A dehydration indicator of serum osmolality was observed as a predictor of the chronic diseases hypertension, diabetes mellitus, and kidney disease.