Hollow Bismuth Nanoparticle-Loaded Gelatin Hydrogel Regulates M2 Polarization of Macrophages to Promote Infected Wound Healing
Hollow Bismuth Nanoparticle-Loaded Gelatin Hydrogel Regulates M2 Polarization of Macrophages to Promote Infected Wound Healing
Dongming Lv(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Zhongye Xu(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Hao Yang(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Yanchao Rong(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Zirui Zhao(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Zhicheng Hu(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Rong Yin(Department of Dermatology, the First Affiliated Hospital of Sun Yat-sen University); Rui Guo(Department of Biomedical Engineering, Jinan University); Xiaoling Cao(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University); Bing Tang(Department of Burns, Wound Repair and Reconstruction, the First Affiliated Hospital of Sun Yat-sen University)
28권, 1505~1518쪽
초록
Open wounds face severe bacterial infection, which affects the quality of healing. Photothermal antimicrobial therapy has received increasing attention as a broad-spectrum antimicrobial treatment that can avoid drug resistance. A variety of metallic materials have been used in the development of photothermal agents. However, there are few studies on bismuth as a photothermal agent and its use in tissue repair, so there is still a lack of clear understanding of its biomedical function. Here, a hollow bismuth nanosphere prepared from bismuth metal was developed for drug loading and photothermal antibacterial effect. The photothermal conversion efficiency of the hollow bismuth spheres reached 16.1%, and the bismuth-loaded gelatin-oxidized dextran (ODex)-based hydrogel achieves good antibacterial effects both in vivo and in vitro. The bismuth-loaded hydrogel can also promote the angiogenesis of human umbilical vein endothelial cells (HUVECs) and improve the proliferation of human keratinocytes cells (HaCaT) and the quality of wound healing. This discovery provides a new idea for the application of metal bismuth in the field of tissue repair and regeneration.
Abstract
Open wounds face severe bacterial infection, which affects the quality of healing. Photothermal antimicrobial therapy has received increasing attention as a broad-spectrum antimicrobial treatment that can avoid drug resistance. A variety of metallic materials have been used in the development of photothermal agents. However, there are few studies on bismuth as a photothermal agent and its use in tissue repair, so there is still a lack of clear understanding of its biomedical function. Here, a hollow bismuth nanosphere prepared from bismuth metal was developed for drug loading and photothermal antibacterial effect. The photothermal conversion efficiency of the hollow bismuth spheres reached 16.1%, and the bismuth-loaded gelatin-oxidized dextran (ODex)-based hydrogel achieves good antibacterial effects both in vivo and in vitro. The bismuth-loaded hydrogel can also promote the angiogenesis of human umbilical vein endothelial cells (HUVECs) and improve the proliferation of human keratinocytes cells (HaCaT) and the quality of wound healing. This discovery provides a new idea for the application of metal bismuth in the field of tissue repair and regeneration.
- 발행기관:
- 한국생체재료학회
- 분류:
- 의공학