비색법을 이용한 젤네일 유효성분 방출 특성 분석 연구

This study aimed to quantitatively analyze the release behavior of panthenol, a functional active ingredient, from gel nail formulations using a colorimetric method. Gel samples were prepared by formulating control (without panthenol), 1% panthenol (P1), and 3% panthenol (P3) groups, and were fully cured using a UV/LED lamp for 30, 60, and 90 seconds, respectively. After a 5-minute natural drying process, the amount of panthenol released over time (2, 4, 8, and 24 hours) was measured. The extracted panthenol was hydrolyzed, reacted with Duquenois reagent, and analyzed by UV/Vis spectrophotometry at 406 nm. The standard calibration curve showed excellent linearity (R² = 0.9999), enabling accurate quantification of the released panthenol. Experimental results indicated that absorbance values increased over time in all groups (control, P1, P3). Both P1 and P3 groups exhibited a significant time-dependent increase in panthenol release, with P3 showing the highest absorbance at 24 hours. A statistically significant interaction effect between time and formulation was observed (p < 0.0001). P1 exhibited a delayed initial release but achieved a high cumulative release efficiency (91.76%), whereas P3 demonstrated rapid initial release but a lower overall release efficiency (48.39%). These findings suggest that higher concentrations do not necessarily guarantee greater release efficiency and highlight the importance of optimizing the release mechanism during gel nail formulation design. This study provides foundational data for the development of functional gel nail materials and offers insights into enhancing the usability, convenience, and functionality of gel nail products. Further research is warranted to evaluate the long-term stability of gel formulations and to explore the effects of incorporating various functional active ingredients.