추희 자두(Prunus salicina) 껍질과 과육의 항균, 항염, 세포 독성 특성 비교 연구

This study compared 80% ethanol extracts of the peel and flesh of mature Prunus salicina ‘Chuhui’ plums collected in Korea within a single experimental design to evaluate antibacterial and anti-inflammatory activities, cellular effects, and the feasibility of a part‑specific ingredient strategy. Antibacterial activity against Staphylococcus aureus was assessed by colony‑forming unit reduction; effects on fibroblasts were measured by MTT assay; and anti‑inflammatory activity was determined by TNF‑α levels via ELISA in LPS‑stimulated fibroblasts, using dexamethasone as a control. The peel extract produced 94.2% and 99.8% reductions at 1mg/mL after 12 hours and 48 hours, respectively, outperforming the flesh extract (90.1% and 98.3%), and both parts achieved at least 99.9% reduction at 10mg/mL. Cell viability was 90% or higher at 12 hours under all conditions; however, with the peel extract at 100μg/mL it fell to 70.23% at 24 hours and 67.80% at 48 hours, while the flesh extract maintained 80% or higher across concentrations. In the anti‑inflammatory assay, dexamethasone suppressed TNF‑α by 60.0% at 48 hours; the peel extract at 100μg/mL reached 56.7% and the flesh extract 45.8%, indicating time‑dependent inhibition. Overall, the peel acts as an efficacy‑focused active with strong antibacterial and anti‑inflammatory properties, the flesh serves as a biocompatible base, and high‑dose or prolonged use of the peel warrants safety‑limit setting and delivery optimization; the peel also offers a sustainable, high‑value upcycling resource from fruit‑processing by products.